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Findings show increasing mitochondrial DNA in urine reflects metabolic stress in chronic kidney disease, suggesting biomarker potential.
Our findings indicate a progressive increase in urine cell pellet mtDNA-CN across healthy individuals, NDCKD, and DCKD. This pattern, particularly in DCKD, may reflect a compensatory mitochondrial response to metabolic stress, suggesting mtDNA-CN as a promising noninvasive biomarker for disease monitoring.
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Chellam et al. (2026) studied this question.
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