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February 25, 2026RSC AdvancesOpen Access

Development of dual acting selenium-doped hydroxyapatite nanoparticles with platinum-bisphosphonate complexes for bone cancer therapy

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Authors

ABAlessandra BarbanenteACAnna Maria Di CosolaFRFederica Rizzi

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Overview

Demonstrates a dual-action biomaterial enhancing cancer treatment in bones, indicating its therapeutic potential.

Key Points

  • The aim is to develop nanoparticles that effectively target bone cancer using dual mechanisms.
  • Synthesis of selenium-doped hydroxyapatite nanoparticles
  • Incorporation of platinum-bisphosphonate complexes
  • Evaluation of antiproliferative activity
  • Assessment of reactive oxygen species involvement
  • PtBP-HASe nanoparticles show significant antiproliferative activity against cancer cells
  • Reactive oxygen species contribute to the effectiveness of the treatment
  • The nanoparticles successfully target bone tissue.

Cite This Study

Barbanente et al. (2026) studied this question.

synapsesocial.com/papers/699e927bf5123be5ed050394https://doi.org/10.1039/d5ra09348a
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