Metal-Free, Iodine-Mediated Multicomponent Synthesis of Bis-Pyrazolo-Pyridine Derivatives

Karuppaiah Perumal; Markabandhu Shanthi; Vijayakumar Hemamalini; Bhaskaran Shankar; Subburethinam Ramesh

doi:10.1039/d6cc00245e

January 1, 2026Chemical Communications

Metal-Free, Iodine-Mediated Multicomponent Synthesis of Bis-Pyrazolo-Pyridine Derivatives

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Key Points

The aim is to develop a metal-free synthesis method for bis-pyrazolo-pyridine derivatives.
Developed a one-pot synthesis protocol using iodine mediation.
Utilized readily available substrates such as pyrazole amines and phenylhydrazine hydrochloride.
Established a metal-free and efficient approach for synthesizing pyrazolo-fused pyridines.

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Implication

A one-pot iodine-mediated synthesis reduces complexity for pyrazolo-fused pyridines using common substrates.

Abstract

A one-pot, iodine-mediated, metal-free protocol has been developed for the synthesis of pyrazolo-fused pyridines from pyrazole amines, phenylglyoxal monohydrate, and phenylhydrazine hydrochloride. This method uses readily available substrates, offers a...

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Perumal et al. (2026) studied this question.

synapsesocial.com/papers/699f956d1bc9fecf3dab318d https://doi.org/10.1039/d6cc00245e

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Metal-Free, Iodine-Mediated Multicomponent Synthesis of Bis-Pyrazolo-Pyridine Derivatives

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Metal-Free, Iodine-Mediated Multicomponent Synthesis of Bis-Pyrazolo-Pyridine Derivatives

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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