Systolic Blood Pressure Targets in Patients With Hypertension With and Without Cardiovascular Disease: A Pooled Analysis of 4 Randomized Clinical Trials

Key Points

• To investigate the relationship between systolic blood pressure targets and cardiovascular risk in patients with hypertension, with and without cardiovascular disease.
• Pooled analysis of 4 randomized clinical trials
• Utilized restricted cubic spline analyses to examine associations
• Examined achieved systolic blood pressure levels and cardiovascular outcomes
• Demonstrated a J-shaped association between achieved systolic blood pressure and major adverse cardiovascular events
• Lower cardiovascular risk linked to systolic blood pressure maintained between 110 to 140 mm Hg
• Optimal risk observed at systolic blood pressure levels between 120 and 130 mm Hg
• Identified potential additional benefits for patients without cardiovascular disease with targets below 110 mm Hg