Palladium/copper bimetallic system-catalyzed cascade cyclization of N-allyl Ynamides and o-haloanilines: access to multifunctional benzimidazoles

Key Points

• To explore a one-pot synthesis method for 1,2-disubstituted multifunctional benzimidazole derivatives.
• Utilized N-Allyl Ynamides and o-Haloanilines for synthesis
• Conducted mechanistic studies to understand the reaction pathway
• Employed palladium as a catalyst in the process.
• Successfully synthesized multifunctional benzimidazole derivatives
• Confirmed the reaction proceeds via Pd-catalyzed nucleophilic addition