Differences in Vascular Responses and Underlying Mechanisms Following Paclitaxel-Coated Balloon Angioplasty Between Lipid-Rich and Non-Lipid-Rich Lesions in Chronic Coronary Syndrome.

Yutaka Matsuhiro; Masami Nishino; Hiroaki Nohara; Shodai Kawanami; Koji Yasumoto; Naotaka Okamoto; Ryu Shutta; Masamichi Yano; Daisuke Nakamura; Isamu Mizote; Yasushi Sakata; Jun Tanouchi

doi:10.1002/ccd.70534

February 24, 2026

Differences in Vascular Responses and Underlying Mechanisms Following Paclitaxel-Coated Balloon Angioplasty Between Lipid-Rich and Non-Lipid-Rich Lesions in Chronic Coronary Syndrome.

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Key Points

The aim is to investigate how vascular responses differ between lipid-rich and non-lipid-rich lesions after Paclitaxel-coated balloon therapy.
Comparison of vascular outcomes following treatment with Paclitaxel-coated balloons.
Assessment of lipid burden in coronary lesions.
Analysis of LLE and maxLCBI<sub>4</sub>mm metrics.
Paclitaxel treatment improved outcomes like LLE regardless of lipid burden.
Differences in underlying mechanisms were noted between the two types of lesions.

Implication

Findings reveal different biological responses after Paclitaxel treatment in coronary lesions, suggesting implications for DCB therapy.

Abstract

Paclitaxel-coated balloon treatment was associated with favorable outcomes, including LLE and a reduction in maxLCBI₄mm, irrespective of lipid burden. However, the mechanisms underlying LLE may differ between lipid-rich and non-lipid-rich lesions, suggesting potential heterogeneity in biological responses to DCB therapy.

Discussion

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Cite This Study

Matsuhiro et al. (2026) studied this question.

synapsesocial.com/papers/699f95ba1bc9fecf3dab3d4d https://doi.org/10.1002/ccd.70534

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Differences in Vascular Responses and Underlying Mechanisms Following Paclitaxel-Coated Balloon Angioplasty Between Lipid-Rich and Non-Lipid-Rich Lesions in Chronic Coronary Syndrome.

Key Points

Implication

Abstract

Discussion

Cite This Study

Differences in Vascular Responses and Underlying Mechanisms Following Paclitaxel-Coated Balloon Angioplasty Between Lipid-Rich and Non-Lipid-Rich Lesions in Chronic Coronary Syndrome.

Key Points

Implication

Abstract

Discussion

Cite This Study

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