Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians

Key Points

• The central aim is to evaluate the effectiveness and harms of COVID-19 vaccines in adults who are not pregnant or immunocompromised.
• Conducted a rapid review
• Included data on vaccine effectiveness
• Assessed comparative effectiveness against various strains
• Evaluated adverse effects reported in literature
• COVID-19 vaccines show significant protective effects against infection and severe disease.
• Minor side effects reported in most cases, while serious harms are rare.
• Comparative effectiveness varies slightly between vaccine types but overall benefits outweigh risks.