Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians

Q: What does this research mean for the field?

COVID-19 vaccines are effective and have a favorable safety profile in adults who are not pregnant or immunocompromised. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Andreea Cristina Dobrescu; Larisa Pinte; Amin Sharifan; Arianna Gadinger; Isabel Moser; Christopher Cooper; Gerald Gartlehner

doi:10.7326/annals-25-05044

February 23, 2026Annals of Internal Medicine

Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians

View at Publisher

Ask AI

Bookmark

Share

Key Points

The central aim is to evaluate the effectiveness and harms of COVID-19 vaccines in adults who are not pregnant or immunocompromised.
Conducted a rapid review
Included data on vaccine effectiveness
Assessed comparative effectiveness against various strains
Evaluated adverse effects reported in literature
COVID-19 vaccines show significant protective effects against infection and severe disease.
Minor side effects reported in most cases, while serious harms are rare.
Comparative effectiveness varies slightly between vaccine types but overall benefits outweigh risks.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

A rapid review examines the effectiveness and harms of COVID-19 vaccines in non-immunocompromised adults, highlighting important implications for public health.

Abstract

American College of Physicians. (PROSPERO: CRD420251136017).

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Dobrescu et al. (2026) studied this question.

synapsesocial.com/papers/699fe24b95ddcd3a253e6197 https://doi.org/10.7326/annals-25-05044

View at Publisher

Ask AI

Bookmark

Share

Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading