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February 26, 2026Journal of Nanobiotechnology2 citationsOpen Access

Neutrophil-mediated delivery of curcumin-loaded manganese-doped zeolitic imidazolate framework-8 nanozymes for pulmonary arterial hypertension

CDChun DaiXLXiang LiTCTian-Shu Chu

Key Points

  • This research aims to assess a novel cell-based nanoplatform for treating pulmonary arterial hypertension (PAH).
  • Developed a neutrophil-mediated delivery system for curcumin-loaded manganese-doped nanostructures.
  • Evaluated antioxidant and anti-inflammatory effects in a cellular model of PAH.
  • Assessed the impact on EndoMT inhibition to regulate vascular remodeling.
  • Demonstrated significant alleviation of PAH symptoms in the tested model.
  • Observed strong antioxidant and anti-inflammatory effects of the nanoplatform.
  • Inhibition of EndoMT was confirmed, indicating a mechanism to prevent vascular remodeling.

Abstract

NEMZC represents a safe, targeted, and multifunctional cell‑based nanoplatform that effectively alleviates PAH through dual antioxidant/anti‑inflammatory action and EndoMT inhibition, demonstrating strong potential for clinical translation.

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Cite This Study

Dai et al. (2026) studied this question.

synapsesocial.com/papers/699fe24b95ddcd3a253e62e5https://doi.org/10.1186/s12951-026-04148-0
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