Association between serum pyridoxal 5'-phosphate and kidney stone risk: neutrophil count as a partial mediator

Di Chen; Wenju Fan; Qiufeng Zhou; Chengxin Li; Pengnan Hu; Gaomeng Wei

doi:10.1186/s40001-026-04077-6

February 23, 2026European journal of medical researchOpen Access

Association between serum pyridoxal 5'-phosphate and kidney stone risk: neutrophil count as a partial mediator

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Key Points

To investigate the relationship between serum pyridoxal 5'-phosphate and kidney stone risk, considering inflammation's mediating effect.
Focused on participants with BMI between 25-29.9.
Excluded individuals with diabetes and hypertension.
Analyzed the correlation between serum PLP levels and kidney stone risk.
Higher serum PLP levels corresponded with reduced kidney stone risk.
Inflammation indicators, like neutrophil count, partially mediated this association.

Implication

Observational analysis shows lower kidney stone risk with higher pyridoxal 5'-phosphate in those with specific BMI, suggesting inflammatory role.

Abstract

Among participants with a BMI of 25-29.9, without diabetes or hypertension, higher serum PLP levels were associated with a lower KS risk. Inflammation may affect the association between PLP and KS risk.

Discussion

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/699fe28895ddcd3a253e63be https://doi.org/10.1186/s40001-026-04077-6

View Full Paper

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Association between serum pyridoxal 5'-phosphate and kidney stone risk: neutrophil count as a partial mediator

Key Points

Implication

Abstract

Discussion

Cite This Study

Association between serum pyridoxal 5'-phosphate and kidney stone risk: neutrophil count as a partial mediator

Key Points

Implication

Abstract

Discussion

Cite This Study

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