⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

February 23, 2026

Association Analysis of HSF1 Variable Number Tandem Repeat Expansion and Coding Variants with Essential Tremor Risk in a Large Cohort.

Sheng Zeng Yuwen Zhao Dong Chang Yuzheng Wang Mingqiang Li Beisha Tang Qiying Sun

View at Publisher

Ask AI

Bookmark

Share

Key Points

This research examines the potential link between HSF1 variants and the risk of essential tremor.
Analyzed HSF1 variable number tandem repeat (VNTR) expansions
Investigated rare damaging coding variants
Utilized a large cohort for comprehensive risk assessment
No significant association found between HSF1 VNTR and essential tremor risk
Rare coding variants not identified as major risk factors for the condition

Implication

Analysis identifies no significant risk from HSF1 variants for essential tremor, suggesting alternative factors may be involved.

Abstract

Our data do not support HSF1 VNTR or rare damaging coding variants as major risk factors for ET. © 2026 International Parkinson and Movement Disorder Society.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/699fe32295ddcd3a253e6d11 https://doi.org/10.1002/mds.70243

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Assessing Intronic Variable Number Tandem Repeat ( <scp>VNTR)</scp> Expansions of the <scp> <i>HSF1</i> </scp> Gene in Essential Tremor Patients from Eastern ChinaOriginal Research · 2026
2Independent Validation and Structural Characterization of Expanded <scp> <i>HSF1</i> </scp> Intronic Variable Number Tandem Repeats in Essential TremorOriginal Research · 2026
3No role of intronic expansions in HSF1 for essential tremor in EuropeOriginal Research · 2026
4Genetic Analysis of the SLC38A6 Gene in Chinese Patients with Essential Tremor: Not Causative, But Rather an Additional Susceptibility Gene?Original Research · 2026
5An Exploratory Analysis of Essential Tremor and Associated Phenotypes2025

Polygenic and spatial insights into the genetic uniqueness of essential tremor using common variants2026
Association of Non‐Coding Repeat Expansions with Parkinson's Disease Risk: Evidence from a <scp>UK</scp> Biobank‐Based Whole‐Genome Sequencing Study2025
Short tandem repeat expansions in patients with neurodegenerative dementia2026

More from Central South University

More from Xiangya Hospital Central South University

More from Second Xiangya Hospital of Central South University

More from University of South China

More from First Affiliated Hospital of University of South China