HClO activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

Q: What does this research mean for the field?

Increased levels of hypochlorous acid (HClO) are associated with ferroptosis-mediated acute alcoholic gastric and liver injury. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Rui WANG; sijie li; Hui Wang; Yongming Yang; Mengjuan Shi; Xue Yu; Peng Lei; Xihua Yang; Shaomin Shuang; Chuan Dong; Li FAN

doi:10.1039/d6cc00671j

January 1, 2026Chemical Communications

HClO activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

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Key Points

The aim is to develop and validate a fluorescent probe for detecting hypochlorous acid in the endoplasmic reticulum during ferroptosis-related injuries.
Developed a near-infrared fluorescent probe (ER-HClO) for detecting HClO.
Evaluated the probe's effectiveness in visualizing HClO levels.
Applied the probe in models of acute alcoholic gastric and liver injury.
Demonstrated increased levels of HClO in the endoplasmic reticulum during ferroptosis.
Visual evidence indicates a significant association between HClO and acute injury.
The probe successfully highlights ferroptosis processes in real-time.

Implication

Investigation reveals increased HClO in ferroptosis-mediated acute gastric and liver injury, suggesting potential diagnostic applications.

Abstract

We present a near-infrared (NIR) fluorescent probe (ER-HClO) for endoplasmic reticulum (ER) hypochlorous acid (HClO) detection. Using ER-HClO, we revealed an increased HClO in ferroptosis-mediated acute alcoholic gastric and liver...

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Cite This Study

WANG et al. (2026) studied this question.

synapsesocial.com/papers/699fe33695ddcd3a253e6dcb https://doi.org/10.1039/d6cc00671j

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HClO activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

Key Points

Implication

Abstract

Discussion

Cite This Study

HClO activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

Key Points

Implication

Abstract

Discussion

Cite This Study

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