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January 1, 2026Physical Chemistry Chemical Physics

Discovery of a new binding site for the possible gain in neomorphic activity in R132H_IDH1

Nandeshwar Nandeshwar Abhipsa Sekhar Biswal Soumit Chatterjee Umakanta Tripathy

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Key Points

To identify a new binding site associated with neomorphic activity in the R132H_IDH1 variant.
Characterization of IDH1 catalytic activity in vitro
Biochemical assays to assess binding affinity
Structural analysis using X-ray crystallography
Discovery of a novel binding site that enhances neomorphic activity
Increased catalytic efficiency observed in the R132H_IDH1 variant
Potential implications for targeted therapies in related diseases

Implication

Reveals a new binding site that may enhance neomorphic activity in the R132H variant of IDH1, suggesting potential therapeutic targets.

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Cite This Study

Nandeshwar et al. (2026) studied this question.

synapsesocial.com/papers/699fe34695ddcd3a253e705e https://doi.org/10.1039/d5cp04261e

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