Establishing Parameters for Resonant Acoustic Mixing (RAM) Chemistry using Buchwald-Hartwig Amination as a Model

Q: What does this research mean for the field?

Resonant Acoustic Mixing (RAM) can be effectively utilized to control the parameters of Buchwald-Hartwig Amination reactions in a scalable and environmentally-friendly manner. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Lori Gonnet; Cameron B. Lennox; Tristan H Borchers; Mohammad S. Askari; Alexander Wahrhaftig-Lewis; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friscic

doi:10.1039/d6gc00784h

January 1, 2026Green ChemistryOpen Access

Establishing Parameters for Resonant Acoustic Mixing (RAM) Chemistry using Buchwald-Hartwig Amination as a Model

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Key Points

The research aims to establish essential parameters for controlling Resonant Acoustic Mixing (RAM) in chemical reactions, focusing on Buchwald-Hartwig amination.
Analyzed the reaction environment for RAM chemistry.
Utilized Buchwald-Hartwig amination as a model reaction.
Investigated parameters affecting synthesis control in mechanochemical processes.
Identified key parameters that govern the efficiency of RAM.
Demonstrated that RAM can effectively enhance reaction outcomes in the model amination process.

Implication

Explores how resonant acoustic mixing affects reaction control in synthesis, suggesting a new eco-friendly methodology.

Abstract

While Resonant Acoustic Mixing (RAM) has been proposed as a scalable methodology for environmentally-friendly synthesis, notably media-free mechanochemical synthesis, the underlying reaction environment and the parameters that govern reaction control,...

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Cite This Study

Gonnet et al. (2026) studied this question.

synapsesocial.com/papers/699fe35995ddcd3a253e716d https://doi.org/10.1039/d6gc00784h

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Establishing Parameters for Resonant Acoustic Mixing (RAM) Chemistry using Buchwald-Hartwig Amination as a Model

Key Points

Implication

Abstract

Discussion

Cite This Study

Establishing Parameters for Resonant Acoustic Mixing (RAM) Chemistry using Buchwald-Hartwig Amination as a Model

Key Points

Implication

Abstract

Discussion

Cite This Study

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