Investigate the effects of topical fisetin on wound healing in diabetic mice, focusing on senescence and inflammation.
Applied fisetin topically to diabetic mice with skin wounds
Assessed wound healing progress through histological analysis
Measured fibrosis and dermal regeneration levels
Topical fisetin significantly reduced fibrosis in the wound area
Enhanced dermal regeneration was observed in fisetin-treated mice
Wound healing dynamics improved compared to control groups
Abstract
Topical fisetin enhances diabetic wound healing by reducing fibrosis and promoting healthy dermal regeneration through senescence and inflammation modulation. Figure: see text.