Structural and mechanistic basis of sulfolytic C–S bond cleavage by an Fe(II)/α-ketoglutarate-dependent sulfoquinovose dioxygenase

Q: What does this research mean for the field?

Sulfoquinovose dioxygenase (SqoD) facilitates bacterial carbon assimilation from sulfoquinovose by cleaving C–S bonds using an Fe(II)/α-ketoglutarate mechanism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mihwa Lee; Ho NN Ho; megan Maher; Guy N. L. Jameson; Spencer J. Williams

doi:10.1039/d5sc09188h

January 1, 2026Chemical ScienceOpen Access

Structural and mechanistic basis of sulfolytic C–S bond cleavage by an Fe(II)/α-ketoglutarate-dependent sulfoquinovose dioxygenase

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Key Points

To investigate the structural and mechanistic aspects of sulfoquinovose dioxygenase (SqoD) facilitating C–S bond cleavage.
Determined crystal structures of SqoD from Marinobacterium aestuarii
Analyzed the interaction between Fe(II) and α-ketoglutarate in the cleavage process
Identified key structural features of SqoD involved in enzymatic function
Demonstrated the pathway of carbon assimilation through the cleavage of the C–S bond

Implication

Crystal structures reveal mechanisms of C–S bond cleavage in sulfoquinovose dioxygenase, aiding bacterial carbon assimilation.

Abstract

Sulfoquinovose dioxygenase (SqoD) enables bacterial carbon assimilation from the abundant sulfosugar sulfoquinovose (SQ) by Fe(II)/α-ketoglutarate (αKG)–dependent C–S bond cleavage. Here we report crystal structures of the Marinobacterium aestuarii enzyme ( Ma SqoD)...

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/699fe39d95ddcd3a253e7922 https://doi.org/10.1039/d5sc09188h

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Structural and mechanistic basis of sulfolytic C–S bond cleavage by an Fe(II)/α-ketoglutarate-dependent sulfoquinovose dioxygenase

Key Points

Implication

Abstract

Discussion

Cite This Study

Structural and mechanistic basis of sulfolytic C–S bond cleavage by an Fe(II)/α-ketoglutarate-dependent sulfoquinovose dioxygenase

Key Points

Implication

Abstract

Discussion

Cite This Study

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