Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA-Seq Analysis.

Sandra Pohl; M Huber; Tobias Akamp; Andreas Rosendahl; Melanie Linnebank; Lea Schreiber; Claudia Gebhard; Nicholas Strieder; Michael Rehli; Wolfgang Buchalla; Matthias Widbiller

doi:10.1111/iej.70117

February 23, 2026

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA-Seq Analysis.

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Key Points

This research aims to investigate the transcriptomic differences in dental pulp subpopulations in response to S. mutans exposure.
Isolated dental pulp cells (DACs and DPCs) were mechanically separated.
Bulk RNA sequencing (RNA-Seq) was conducted to analyze transcriptomic profiles.
Comparison of responses between DACs and DPCs post S. mutans exposure was performed.
DACs showed enhanced activation of immunomodulatory pathways.
DPCs demonstrated significant markers for cellular stress responses.
Distinct functional roles were suggested for DACs and DPCs in tissue defense and homeostasis.

Implication

Bulk RNA-Seq analysis reveals diverse immune responses in dental pulp cells, indicating distinct roles in tissue defense.

Abstract

Following exposure to S. mutans, mechanically isolated DACs and DPCs displayed distinct transcriptomic profiles, indicating functional heterogeneity in the pulpal immune response. DACs engaged immunomodulatory pathways, while DPCs were marked by cellular stress responses, suggesting divergent contributions to tissue defence and homeostasis.

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Cite This Study

Pohl et al. (2026) studied this question.

synapsesocial.com/papers/699fe39d95ddcd3a253e7a32 https://doi.org/10.1111/iej.70117

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Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA-Seq Analysis.

Key Points

Implication

Abstract

Discussion

Cite This Study

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA-Seq Analysis.

Key Points

Implication

Abstract

Discussion

Cite This Study

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