Prospective observational study uncovers impaired oocyte and embryo quality in women with endometriosis, suggesting new ART strategies.
Key Points
This study aims to explore the inflammatory profiles associated with endometriosis and their impact on oocyte and embryo quality during assisted reproductive technologies.
Monocentric observational study with 47 women undergoing controlled ovarian stimulation for ART
Comparison of 29 endometriosis patients with 18 controls (tubal or male-factor infertility)
Quantification of cytokines in serum and follicular fluid
Evaluation of embryo quality using static morphology and dynamic time-lapse monitoring
Endometriosis patients showed higher pro-inflammatory cytokines and lower anti-inflammatory IL-10
Diminished ovarian reserve and reduced oocyte yield in the endometriosis group
Lower fertilization rates and increased multinucleation in embryos from endometriosis patients
Significantly lower clinical pregnancy rates in the endometriosis group