Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption

Muhammad Bilal Hassan Mahboob; Jessica R. Tait; Dovile Anderson; Maytham Hussein; John F. Quinn; Tony Velkov; Darren J. Creek; Michael R. Whittaker; Cornelia B. Landersdorfer

doi:10.1039/d5bm01485a

January 1, 2026Biomaterials Science

Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption

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Key Points

The aim is to investigate how cationic lipidated oligomers affect MRSA membranes through metabolomic analysis.
Used untargeted metabolomics to analyze MRSA membranes
Examined the effects of two structurally distinct CLOs on lipid profiles
Performed comparative analysis of membrane disruptions
Distinct changes in MRSA membrane lipids were identified
CLOs cause specific lipid disruptions indicative of membrane damage
Differences in lipid disruption patterns between the two CLOs were observed

Implication

Untargeted metabolomics shows lipid disruptions in MRSA, indicating potential antimicrobial applications of CLOs.

Abstract

Untargeted metabolomics uncovers distinct membrane-lipid disruptions in MRSA triggered by two structurally distinct cationic lipidated oligomers (CLOs).

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Cite This Study

Mahboob et al. (2026) studied this question.

synapsesocial.com/papers/699fe3ec95ddcd3a253e80b3 https://doi.org/10.1039/d5bm01485a

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Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption

Key Points

Implication

Abstract

Discussion

Cite This Study

Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption

Key Points

Implication

Abstract

Discussion

Cite This Study

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