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February 26, 2026Biomaterials Science1 citations

Betulinic acid exacerbates biomolecular condensation of α-synuclein: Possible role in Parkinson's Disease

SBSoumojit BiswasNational Institute of Pharmaceutical Education and ResearchKPKarthik PNational Institute of Pharmaceutical Education and ResearchNMNimisha A Mavlankar

Key Points

  • The study investigates how betulinic acid affects aggregation of α-synuclein, which is linked to Parkinson's disease.
  • Assessment of α-synuclein biomolecular condensation
  • Analysis of amyloid structure formation
  • Comparison of conditions with and without betulinic acid
  • Betulinic acid significantly increases the formation of α-synuclein amyloid structures.
  • Findings suggest a correlation between betulinic acid exposure and progression of pathological features associated with Parkinson's disease.

Abstract

Aggregation of α-synuclein (α-SYN) into amyloid structures is closely linked to progression of Parkinson's disease (PD). Type 2 diabetes mellitus increases PD risk, sharing common pathological features like amyloid aggregation,...

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Cite This Study

Biswas et al. (2026) studied this question.

synapsesocial.com/papers/699fe40c95ddcd3a253e83b8https://doi.org/10.1039/d5bm01817j
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