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February 27, 2026SHILAP Revista de lepidopterologíaOpen Access

Molecular cartilage pathology following anterior cruciate ligament reconstruction: a systematic review of MRI studies

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Authors

AAAbdulmajeed Alfayyadh

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Overview

Systematic review synthesizes MRI findings on cartilage changes post ACL reconstruction, suggesting significant abnormality implications.

Key Points

  • The aim is to synthesize MRI evidence related to tibiofemoral cartilage changes after ACL reconstruction and identify associated factors.
  • Conducted a systematic review covering studies published from 2000 to 2025.
  • Evaluated tibiofemoral cartilage using quantitative or compositional MRI.
  • Reviewed studies were assessed for methodological quality and risk of bias.
  • Meta-analysis was performed where possible for comparable outcomes.
  • ACLR knees showed elevated T2 relaxation times and T1 ρ values compared to healthy controls.
  • Most abnormalities were found in the medial compartment of the knee, especially over longer follow-ups.
  • Meniscal pathology and altered biomechanics were linked to poorer cartilage outcomes.
  • Meta-analysis indicated higher tibiofemoral T2 in ACLR knees with significant variability among studies.

Cite This Study

Abdulmajeed Alfayyadh (2026) studied this question.

synapsesocial.com/papers/69a1344fed1d949a99abe13fhttps://doi.org/10.3389/fsurg.2026.1714750
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Articular Cartilage Arthrokinematics and Compositional Measurements With qMRI 1 to 2 Years After ACL Reconstruction With Meniscal Surgery.2025
  2. 2Five-Year Clinical and MRI-Based Outcomes After Cartilage Repair With or Without ACL Reconstruction: Worse Clinical Outcome after ACL Reconstruction Does not Affect Cartilage Repair Tissue Quality.2025
  3. 3Quantitative Investigation of Tibiofemoral Cartilage Early Degeneration After ACL Reconstruction: An Integrated Biomechanical and Longitudinal MRI Analysis2026
  4. 4Magnetic resonance imaging findings in chronic anterior cruciate ligament‐deficient knees: A systematic review of meniscal, cartilage, tibial translation and ligamentous changes2026 · 1 citations
  5. 5Primary anterior cruciate ligament repair—morphological and quantitative assessment by 7-T MRI and clinical outcome after 1.5 years2024 · 4 citations