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February 27, 2026Frontiers in MicrobiologyOpen Access

Bacterial colonized melanoma skin models allow to study host–microbe interactions in situ

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Authors

ARAline RosinJKJannike Lea KrauseHSHeike Sprenger

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Overview

Proof-of-concept study examines bacterial impact on melanoma biology using 3D models, suggesting new insights into skin cancer dynamics.

Key Points

  • This study aims to investigate how skin bacteria influence melanoma progression in an in situ model.
  • Utilized a 3D melanoma model in an air-liquid interface configuration.
  • Inoculated the model with a diverse bacterial community from healthy human skin.
  • Conducted a 12-day co-cultivation period to assess bacterial counts and impacts.
  • Bacterial counts were comparable to those on human skin in vivo.
  • Significant decline in bacterial diversity observed during co-cultivation.
  • Alterations in gene expression linked to melanoma progression were identified.
  • Cytokine secretion increased, including VEGF and GM-CSF, alongside the melanoma marker MIA.

Cite This Study

Rosin et al. (2026) studied this question.

synapsesocial.com/papers/69a1344fed1d949a99abe17dhttps://doi.org/10.3389/fmicb.2026.1736700
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