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February 27, 2026Clinical and Experimental Medicine1 citationsOpen Access

Immune-Inflammatory Cross-Talk in Atherosclerosis Using AI-Enhanced Multi-Omics

Exploring immune-inflammatory cross-talk in atherosclerosis using AI-enhanced multi-omics approaches

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Authors

ZZZhenzhen ZhaoZZZhijie ZhaoHJHongling Jia

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Overview

Explores immune-inflammation interactions in atherosclerosis, revealing key mechanisms and potential biomarkers.

Key Points

  • The research aims to characterize vascular smooth muscle cell (VSMC) subsets and their role in atherosclerosis using advanced multi-omics approaches.
  • Integrated single-cell transcriptomics with spatial transcriptomics
  • Conducted in vitro functional assays for VSMCs
  • Analyzed cell interactions using signaling pathways
  • Validated findings through apoptosis and cell viability assays
  • Identified a distinct LUM + VSMC subpopulation with high plasticity and inflammation
  • LUM promotes VSMC proliferation and interacts with endothelial cells and macrophages
  • Highlighted new potential biomarkers for precision diagnostics in vascular diseases

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69a134b8ed1d949a99abe43chttps://doi.org/10.1007/s10238-026-02062-1
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