Concordance analysis evaluates mismatch repair deficiency and microsatellite instability in endometrial and colorectal cancer, highlighting the need for tumor-specific interpretation.
These findings confirm the lower concordance between MMR-IHC and MSI-NGS in endometrial cancer compared with colorectal cancer when broad panels are used, underscoring the importance of tumor-specific interpretation even within tumor-agnostic assays. Although cut-off optimization improved agreement, the evidence remains insufficient for clinical implementation, and further validation studies are needed.
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Nero et al. (2026) studied this question.
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