What question did this study set out to answer?

The review clarifies how lysine lactylation affects hepatocellular carcinoma (HCC) biology and its potential as a predictive biomarker.

February 27, 2026Shengming kexue

Research progress on the role of lactylation modification in the development of hepatocellular carcinoma

View Full Paper

Ask AI

Bookmark

Authors

This comprehensive review evaluates the impact of lactylation on hepatocellular carcinoma, suggesting new treatment strategies and biomarkers.

The review clarifies how lysine lactylation affects hepatocellular carcinoma (HCC) biology and its potential as a predictive biomarker.
Comprehensive review of recent proteomic data from in-vitro, in-vivo, and clinical studies
Analysis of lactate's role in HCC development
Evaluation of lactylation mechanisms and their impact on cancer aggressiveness
Lactate accumulation is linked to significant HCC progression and aggressiveness
Lactylation levels correlate with tumor grade and patient survival
Proposed treatments include lactate-lowering agents and lactylation-targeted therapies that re-sensitize HCC to immunotherapy

Wu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

This comprehensive review evaluates the impact of lactylation on hepatocellular carcinoma, suggesting new treatment strategies and biomarkers.