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This review aims to elucidate the dual regulatory role of phospholipase D in autophagy, highlighting its implications in various diseases.

February 27, 2026Shengming kexue

Bidirectional regulation of autophagy by PLD: a target for disease treatment

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This review explores the dual role of phospholipase D in regulating autophagy, indicating a potential therapeutic target for diseases.

This review aims to elucidate the dual regulatory role of phospholipase D in autophagy, highlighting its implications in various diseases.
Analysis of phospholipase D's interaction with autophagy pathways.
Exploration of microenvironmental and contextual factors influencing PLD activity.
Discussion of disease-specific roles of PLD in regulating autophagy.
PLD has abidirectional influence on autophagy, promoting it in glioblastoma and breast cancer while inhibiting it in cervical and colorectal cancers.
Deficient PLD activity contributes to impaired autophagy in neurodegenerative disorders like Alzheimer's and Parkinson's diseases.
Altered PLD-autophagy signaling is linked to liver diseases and polycystic kidney disease.

XIAO et al. (2026) studied this question.

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