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February 27, 2026Thrombosis JournalOpen Access

Trends and disparities in disseminated intravascular coagulation-related mortality among adults aged 25 and above in the U.S., 1999–2020: CDC WONDER insights

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Authors

MSMadiha SaleemJinnah Sindh Medical UniversityMMMuhammad Salman MustafaDow University of Health SciencesASAreeba ShafiqDow University of Health Sciences

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Implication

Analysis reveals rising DIC-related mortality trends in U.S. adults, suggesting urgent need for targeted prevention efforts.

Key Points

  • The aim is to explore trends and disparities in DIC-related mortality among adults in the U.S. from 1999 to 2020.
  • Analyzed death certificate data from the CDC WONDER database.
  • Focused on adults aged 25 and over with DIC as a cause of death.
  • Calculated age-adjusted mortality rates and annual percent change using Joinpoint regression.
  • Stratified data by sex, race/ethnicity, age group, urbanization, and region.
  • 71,241 DIC-related deaths identified from 1999 to 2020.
  • Overall age-adjusted mortality rate declined from 2.1 per 100,000 in 1999 to 1.6 in 2020.
  • Non-Hispanic Black adults had the highest mortality rate at 2.8.
  • Mortality increased since 2017, particularly among men and Black adults.

Cite This Study

Saleem et al. (2026) studied this question.

synapsesocial.com/papers/69a134fbed1d949a99abe76dhttps://doi.org/10.1186/s12959-026-00848-7
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