Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems.

Richard G. Künzel; Yinxian Chen; Marta B. Rondón; Diana L. Juvinao-Quintero; Laramie Duncan; E. Sanchez Sixto; Luz G Nateros; Archana Basu; Amantia Ametaj; Clemens Kirschbaum; Elizabeth J. Levey; Bizu Gelaye

doi:10.1111/jcpp.70131

February 25, 2026

Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems.

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Key Points

This study aims to investigate the association between prenatal hair glucocorticoid levels and behavioral problems in children over time.
Analyzed prenatal hair samples for glucocorticoid concentrations
Assessed child behavior problems at multiple developmental stages
Utilized time-dependent modeling techniques for data analysis
Identified significant associations between glucocorticoid levels and behavioral problems
Found that timing of glucocorticoid measurement influenced the strength of the association
Highlighted the importance of prenatal stress in child development

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Implication

Modeling prenatal glucocorticoid levels shows links to behavior problems in children, suggesting insights into stress transmission.

Abstract

We found time-dependent associations between stress-related prenatal hair glucocorticoid concentration and offspring behavioral problems. Modeling biomarker data time-dependently may prove critical to identifying the underlying mechanisms of transgenerational stress transmission.

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Cite This Study

Künzel et al. (2026) studied this question.

synapsesocial.com/papers/69a1350eed1d949a99abe96b https://doi.org/10.1111/jcpp.70131

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Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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