In this cohort study of trauma patients, hypercalcemia was less common than hypocalcemia; however, hypercalcemia was associated with worse mortality at all time points. Blood product consumption was higher among those with hypercalcemia or hypocalcemia compared with eucalcemia but was similar among those with any calcium derangement. Prospective interventional trials are needed to understand the implications of empiric treatment.
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Schauer et al. (Wed,) studied this question.
synapsesocial.com/papers/69a1351ded1d949a99abeaae — DOI: https://doi.org/10.1001/jamanetworkopen.2026.0083
Steven G. Schauer
Combat Medical (Spain)
Susannah E. Nicholson
The University of Texas Health Science Center at San Antonio
Julie A. Rizzo
United States Army Institute of Surgical Research
JAMA Network Open
University of Colorado Denver
The University of Texas Health Science Center at San Antonio
The University of Texas Health Science Center at Houston
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