What question did this study set out to answer?

To compare long-term outcomes of SBRT and HDR brachytherapy for treating intermediate-risk prostate cancer.

February 27, 2026Open Access

SBRT vs HDR Brachytherapy for Intermediate-Risk Prostate Cancer

Key Points

To compare long-term outcomes of SBRT and HDR brachytherapy for treating intermediate-risk prostate cancer.
Post hoc pooled analysis
Used prospective data
Compared biochemical control failure and acute genitourinary adverse events
SBRT resulted in significantly lower biochemical control failure (BCF) rates.
SBRT had significantly fewer acute genitourinary adverse events (AEs).
No significant difference in late patient-reported quality of life (PR-QoL) between the two treatments.

Abstract

This post hoc pooled analysis reports a long-term comparison of SBRT and HDR-BT using prospective data. SBRT had significantly lower BCF and acute genitourinary AEs, and there was no significant difference in late PR-QoL.

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Discussion

Authors

Cristian Udovicich

Sunnybrook Health Science Centre

Patrick Cheung

Sunnybrook Health Science Centre

William Chu

Sunnybrook Health Science Centre

Journals

JAMA Network Open

Actions

Institutions

University of Toronto

Monash University

Western University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

SBRT vs HDR Brachytherapy for Intermediate-Risk Prostate Cancer

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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