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February 25, 2026JAMA Network OpenOpen Access

SBRT vs HDR Brachytherapy for Intermediate-Risk Prostate Cancer

Cristian Udovicich Patrick Cheung William Chu Hans Chung Jay Detsky S. Liu Gerard Morton Chia-Lin Tseng Liu G John M. Hudson Wee Loon Ong Thomas Kennedy Joelle Helou Melanie Davidson Ananth Kumar Ravi M Mcguffin Liying Zhang Alexandre Mamedov Andrea Deabreu Meghan Kulasingham-Poon Andrew Loblaw

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Key Points

To compare long-term outcomes of SBRT and HDR brachytherapy for treating intermediate-risk prostate cancer.
Post hoc pooled analysis
Used prospective data
Compared biochemical control failure and acute genitourinary adverse events
SBRT resulted in significantly lower biochemical control failure (BCF) rates.
SBRT had significantly fewer acute genitourinary adverse events (AEs).
No significant difference in late patient-reported quality of life (PR-QoL) between the two treatments.

Implication

This analysis compares SBRT and HDR brachytherapy outcomes in prostate cancer, highlighting differences in side effects and quality of life.

Abstract

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Cite This Study

Udovicich et al. (2026) studied this question.

synapsesocial.com/papers/69a1351ded1d949a99abeb5d https://doi.org/10.1001/jamanetworkopen.2026.0146

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Outcomes of patients with localized prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy boost: A single-center retrospective study2024
2Long-term outcomes of high-dose-rate brachytherapy combined with moderately hypofractionated external beam radiotherapy for high-risk localized prostate cancerReview · 2026
3A Randomized Trial Comparing Quality of Life After Low-Dose Rate or High-Dose Rate Prostate Brachytherapy Boost With Pelvic External Beam Radiation Therapy2024 · 24 citations
4Long-term outcomes of salvage high-dose-rate brachytherapy for localized recurrence of prostate cancer following definitive radiation therapy: a retrospective analysisCohort Study · 2025 · 2 citations
5Long-term outcomes of high-dose-rate brachytherapy and external beam radiotherapy without hormone therapy for high-risk localized prostate cancer2024 · 5 citations

Radiotherapy in localized prostate cancer: a multicenter analysis evaluating tumor control and late toxicity after brachytherapy and external beam radiotherapy in 1293 patients2024
Long-term outcomes of external beam radiotherapy combined with high-dose-rate brachytherapy boost in intermediate- and high-risk prostate cancer2026
High‐dose‐rate brachytherapy for prostate cancer: Rationale, current applications, and clinical outcome2021
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