Cohort study shows recovery from endocrine suppression in opioid-dependent individuals, highlighting awareness gaps.
Opioid-induced endocrine suppression appears reversible with sustained opioid abstinence. Higher methadone dose, male sex, and depression were associated with hypogonadism. Despite frequent healthcare contact, patients remained undiagnosed, highlighting a gap in clinical awareness of opioid-associated endocrinopathies and the need for routine screening in opioid agonist treatment settings.
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Tremonti et al. (2026) studied this question.
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