Imaging protocol characterizes germinal center architecture in mouse tissues, suggesting advanced visualization techniques.
We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, automated cyclic imaging, image preprocessing, and a new analysis method that detects morphological changes in irregularly shaped stromal cells.
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Molina et al. (2026) studied this question.
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