Mendelian randomization identifies inflammatory cytokines linked to joint pain, suggesting future targeted treatments.
This study identifies IL-18, CTACK, and IL-2RA as potential causal mediators of joint pain, providing genetic evidence that informs future precision approaches to analgesia. Future research should validate these findings across diverse populations and elucidate the molecular mechanisms underlying them to advance targeted therapies.
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Yan et al. (2026) studied this question.
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