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February 27, 2026PLoS ONEOpen Access

A novel mRNA-based multiepitope vaccine candidate against Cryptosporidium hominis and Cryptosporidium parvum employing reverse-vaccinology and immunoinformatics approaches

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Authors

AMAhmad Abdullah MahdeenIHImam HossainMMMd. Habib Ullah Masum

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Overview

In-silico study designs a multiepitope mRNA vaccine targeting gut pathogens, suggesting potential for effective immunization.

Key Points

  • The aim is to develop a novel mRNA vaccine targeting antigens from Cryptosporidium hominis and Cryptosporidium parvum to address cryptosporidiosis.
  • Identified pathogenic proteins associated with Cryptosporidium spp.
  • Designed a multiepitope mRNA vaccine using conserved sequences and epitopes.
  • Conducted structural prediction, docking, and immune simulations.
  • Performed codon optimization for E. coli expression.
  • The vaccine demonstrated standard biophysical properties indicating solubility and stability.
  • Significant receptor-binding affinities were observed for TLR-2 and TLR-4.
  • Immune simulations showed robust immune response amplification upon repeated exposure.

Cite This Study

Mahdeen et al. (2026) studied this question.

synapsesocial.com/papers/69a13550ed1d949a99abf1a9https://doi.org/10.1371/journal.pone.0343643
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