PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 27, 2026Çukurova medical journal (Online)/Çukurova medical journalOpen Access

Effect of Undaria pinnatifida extract on wound healing and pro-inflammatory and anti-inflammatory cytokine modulation

View Full Paper
Ask AI
Bookmark
Share

Authors

KOKadriye Yağmur OruçAOAykut OrucGAGökhan Ağtürk

Discussion

Loading...

Member takes

Overview

Investigates how U. pinnatifida extract affects wound healing and cytokine levels in a human skin cell line.

Key Points

  • The aim is to explore the impact of U. pinnatifida extract on cytokine profiles and wound healing in fibroblasts.
  • Cultured CCD-1072Sk fibroblast cell line and extracted U. pinnatifida.
  • Conducted viability tests and performed Scratch Wound Healing Assay with varying doses.
  • Measured cytokine levels (IL-1β, TNF-α, IL-10, TGF-β1, BDNF) using ELISA at different time points.
  • Assessed apoptosis with Annexin-V-FITC/PI staining and evaluated cell migration.
  • 0.24 µl/ml and 0.5 µl/ml doses of U. pinnatifida significantly improved cell viability at 72 hours compared to control.
  • Best wound closure occurred with 0.5 µl/ml treatment at 72 hours.
  • BDNF and IL-10 levels increased at 72 hours with 0.5 µl/ml, while TNF-α and IL-1β decreased across all time points.

Cite This Study

Oruç et al. (2026) studied this question.

synapsesocial.com/papers/69a1355fed1d949a99abf244https://doi.org/10.17826/cumj.1783528
View Full Paper
Ask AI
Bookmark
Share