Impact of Preoperative Molecular Testing for Indeterminate Nodules on Lobectomy and Completion Thyroidectomy Rates

Caitlin T. Yeo; Jiahui Wu; Sana Ghaznavi; Paul Stewardson; Samar Amanullah; Adrian Box; Markus Eszlinger; Ralf Paschke

doi:10.1530/etj-25-0189

February 25, 2026European Thyroid JournalOpen Access

Impact of Preoperative Molecular Testing for Indeterminate Nodules on Lobectomy and Completion Thyroidectomy Rates

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Key Points

This research aims to evaluate how preoperative molecular testing affects surgery rates for indeterminate nodules.
Analyzed the impact of reflexive molecular testing on thyroid surgery outcomes.
Compared rates of completion thyroidectomy and lobectomy among patients receiving testing.
Examined surgical complications associated with lobectomy versus two-stage thyroidectomy.
Reflexive molecular testing led to a reduction in completion thyroidectomy rates.
Appropriate upfront total thyroidectomy rates increased following testing.
Lobectomy was associated with fewer surgical complications compared to two-stage thyroidectomy.

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Implication

Findings reveal that molecular testing influences thyroid surgery choices, indicating potential benefits for patients.

Abstract

Reflexive MT for ITNs decreased CT rates by increasing appropriate upfront TT. Lobectomy demonstrated lower rates of surgical complications and THR than two-stage thyroidectomy.

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Cite This Study

Yeo et al. (2026) studied this question.

synapsesocial.com/papers/69a1355fed1d949a99abf2e2 https://doi.org/10.1530/etj-25-0189

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Impact of Preoperative Molecular Testing for Indeterminate Nodules on Lobectomy and Completion Thyroidectomy Rates

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Impact of Preoperative Molecular Testing for Indeterminate Nodules on Lobectomy and Completion Thyroidectomy Rates

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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