Impact of Preoperative Molecular Testing for Indeterminate Nodules on Lobectomy and Completion Thyroidectomy Rates | Synapse
February 27, 2026Open Access
Impact of Preoperative Molecular Testing for Indeterminate Nodules on Lobectomy and Completion Thyroidectomy Rates
Key Points
This research aims to evaluate how preoperative molecular testing affects surgery rates for indeterminate nodules.
Analyzed the impact of reflexive molecular testing on thyroid surgery outcomes.
Compared rates of completion thyroidectomy and lobectomy among patients receiving testing.
Examined surgical complications associated with lobectomy versus two-stage thyroidectomy.
Reflexive molecular testing led to a reduction in completion thyroidectomy rates.
Appropriate upfront total thyroidectomy rates increased following testing.
Lobectomy was associated with fewer surgical complications compared to two-stage thyroidectomy.
Abstract
Reflexive MT for ITNs decreased CT rates by increasing appropriate upfront TT. Lobectomy demonstrated lower rates of surgical complications and THR than two-stage thyroidectomy.