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February 27, 2026

Neutrophils in Coronavirus Disease 2019: Guardians or Triggers of Immunopathology?

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Authors

FHFatemeh Mohammadi HenjeroeiNNNiloufar NosratabadiHPHossein Pourghadamyari

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Overview

This review examines neutrophils' role in COVID-19 pathogenesis, revealing their protective yet harmful effects during infection.

Key Points

  • The review aims to clarify the dual roles of neutrophils in COVID-19, emphasizing their mechanisms of protection and potential for causing harm.
  • Review of existing literature on neutrophils in COVID-19
  • Analysis of neutrophil mechanisms like phagocytosis and ROS production
  • Examination of neutrophil plasticity and subsets during infection and recovery
  • Neutrophils are crucial in fighting pathogens but can also lead to tissue damage through cytokine storms.
  • The review details how activated neutrophils contribute to inflammation via ROS and NETs.
  • Distinct neutrophil subsets vary in their responses throughout the course of COVID-19 infection.

Cite This Study

Henjeroei et al. (2026) studied this question.

synapsesocial.com/papers/69a13571ed1d949a99abf4c7https://doi.org/10.1002/cbf.70186
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