What question did this study set out to answer?

To investigate the effects of nontuberculous mycobacteria (NTM) on lung transplantation outcomes in cystic fibrosis patients.

February 27, 20260 citations

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The Role of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis Advanced Lung Disease.

SBShirin Barcikowski RMRibal Bou Mjahed OMOriol Josep Manuel

Key Points

To investigate the effects of nontuberculous mycobacteria (NTM) on lung transplantation outcomes in cystic fibrosis patients.
Analyzed pre- and post-transplant mortality rates in NTM-positive cystic fibrosis patients
Assessed the relationship between NTM infection and chronic lung allograft dysfunction (CLAD)
Conducted comparisons of transplant outcomes between NTM-positive and NTM-negative patients
NTM-positive patients showed lower risk of death or transplantation before transplant
Higher post-transplant mortality was observed in NTM-positive patients
No significant association between NTM infection and CLAD was found

Abstract

NTM-positive CF patients were associated with a lower pre-transplant risk of death or transplantation. Post-transplant mortality was higher in NTM-positive patients, while no association between NTM infection and CLAD was observed. These findings indicate that favorable outcomes after lung transplantation are achievable in NTM-positive patients. Thus, NTM-infection should not be an absolute contraindication for lung transplantation, though careful individual assessment is essential due to the risk of serious complications.

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The Role of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis Advanced Lung Disease.

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