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A before-and-after study shows similar postpartum hemorrhage rates in high-risk women, suggesting effective prophylaxis.
Prophylactic carbetocin was associated with a similar rate of PPH in high-risk women after vaginal delivery, compared with oxytocin, but significantly reduced the use of oxytocin when carbetocin was used as the first-line agent, although there was no difference in the use of prostaglandins or invasive procedures to manage persistent PPH.
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Sauvee et al. (2026) studied this question.