Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease.

Key Points

• To determine the role of vascular smooth muscle cell degeneration in cerebrovascular reactivity impairment in Alzheimer's disease.
• Analyzed the relationship between vascular smooth muscle cell loss and cerebrovascular reactivity.
• Assessed the impact of cerebral amyloid angiopathy and inflammation on vascular function.
• Evaluated vascular integrity as a potential target for therapy in Alzheimer's disease related disorders.
• Identified vascular smooth muscle cell degeneration as a major factor in cerebrovascular reactivity impairment.
• Confirmed that the impairment occurs independently of cerebral amyloid angiopathy.
• Emphasized that vascular integrity could be targeted in therapeutic strategies for Alzheimer's disease.