This case report shows conversion surgery improves outcomes in alpha-fetoprotein producing gastric cancer with metastasis, highlighting treatment potential.
INTRODUCTION: Alpha-fetoprotein–producing gastric cancer (AFPGC) is a rare subtype of gastric cancer associated with poor prognosis due to early liver metastasis. There have been limited reports on conversion surgery following nivolumab combination chemotherapy in cases of AFPGC with liver metastasis. Here, we present a case of alpha-fetoprotein–producing esophagogastric junction cancer (AFP-EGJC) successfully treated with this treatment.
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Akai et al. (2026) studied this question.
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