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February 28, 2026Journal of Neural EngineeringOpen Access

Anatomy-informed recommendations for electrode montage and shape in electrical stimulation methods: A tDCS case study

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Authors

DSDimitrios StoupisSASara Assecondi

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Overview

Case study develops optimized electrode designs for tDCS, improving cognitive enhancement outcomes.

Key Points

  • The research aims to design an anatomy-informed framework for optimizing electrode placements in tDCS to enhance efficacy.
  • Utilized high-resolution MRI data from 590 participants in the Human Connectome Project-Aging.
  • Extracted anatomical features like cortical thickness and sulcal depth.
  • Simulated electric fields using finite-element modeling across different electrode montages.
  • Conducted network-level analyses to evaluate electric field distribution.
  • Montage configuration and individual anatomy significantly influenced the distribution and intensity of induced electric fields.
  • E-fields targeting the dorsolateral prefrontal cortex showed variability in effectiveness.
  • Key determinants of E-field distribution included gyrification index and cortical thickness.
  • Marked variability in peak induced electric fields revealed the challenge of standardizing tDCS protocols.

Cite This Study

Stoupis et al. (2026) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00e9chttps://doi.org/10.1088/1741-2552/ae4a4e
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