Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection

Key Points

• This research aims to explore the antiviral properties of the PERK pathway during human coronavirus 229E infection and the effects of thapsigargin.
• Induced unfolded protein response using thapsigargin
• Evaluated antiviral effects against coronavirus 229E
• Analyzed PERK pathway activation
• Thapsigargin significantly enhances the activity of the PERK pathway
• Inhibition of human coronavirus 229E replication observed with PERK pathway activation
• Revealed potential for thapsigargin as an antiviral agent