Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection

Isabella Pellizzari-Delano; Trinity H. Tooley; Debanjana Mondal; Keya Jani; Carla E. Gallardo-Flores; Che C. Colpitts

doi:10.1039/d5cb00242g

January 1, 2025RSC Chemical BiologyOpen Access

Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection

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Key Points

This research aims to explore the antiviral properties of the PERK pathway during human coronavirus 229E infection and the effects of thapsigargin.
Induced unfolded protein response using thapsigargin
Evaluated antiviral effects against coronavirus 229E
Analyzed PERK pathway activation
Thapsigargin significantly enhances the activity of the PERK pathway
Inhibition of human coronavirus 229E replication observed with PERK pathway activation
Revealed potential for thapsigargin as an antiviral agent

Implication

Broad spectrum antivirals show potential in combating human coronavirus 229E infections, indicating new therapeutic strategies.

Abstract

Broad spectrum antivirals are critical to respond rapidly to the threat posed by newly emerging RNA viruses. One potential candidate is the natural compound thapsigargin (Tg). Tg potently induces endoplasmic...

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Cite This Study

Pellizzari-Delano et al. (2025) studied this question.

synapsesocial.com/papers/69a286490a974eb0d3c01221 https://doi.org/10.1039/d5cb00242g

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Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection

Key Points

Implication

Abstract

Discussion

Cite This Study

Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection

Key Points

Implication

Abstract

Discussion

Cite This Study

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