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Novel compounds enhance singlet oxygen generation in potential photodynamic therapy applications.
New photosensitizers based on cationic porphyrins with an extended π-system have been synthesized. The synthetic strategy involves the use of the Sonogashira cross-coupling reaction to form a conjugated π-system of the macrocycle. The obtained compounds exhibit an absorption peak at 660 nm with an extinction coefficient of ~60 000 M cm; the singlet oxygen quantum yield and the 1-octanol/water partition coefficient were also determined. Absorption in the near-infrared region allows considering the obtained compounds as potential photosensitizers for photodynamic therapy.
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I.O. Savelyeva (2025) studied this question.
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