This research reveals a gold-catalyzed synthesis of functionalized compounds from alkynes and aryl iodides, indicating a new approach for complex chemical processes.
Key Points
The aim is to develop a gold-catalyzed method for the syn-addition of alkynes to aryl iodides, yielding diverse functional products.
Utilized Au(I)/Au(III) catalysis
Conducted tandem oxidative addition and syn-auration
Performed intramolecular annulative cyclization
Achieved product yields of up to 95%
Demonstrated distinct syn-addition compared to traditional anti-addition
Showed excellent functional-group tolerance for pharmaceutical applications