The Effectiveness of Targeted Therapy in the Treatment of Patients with NF2-related schwannomatosis and Vestibular Schwannomas: A Systematic Review

Lay Summary Neurofibromatosis type 2–related schwannomatosis is a rare genetic condition that causes tumors to develop on nerves in the brain and spine, often leading to hearing loss and neurological problems. Standard treatments such as surgery and radiotherapy can control tumor growth but may cause long-term complications. This systematic review examined recent studies on targeted drug treatments designed to slow tumor growth while preserving nerve function. The findings show that targeted therapies can help stabilize tumors, preserve hearing, and maintain quality of life with manageable side effects, highlighting their potential to reduce disability and improve long-term daily functioning.