What question did this study set out to answer?

To investigate the patterns of ASM adherence and discontinuation around pregnancy among individuals with epilepsy.

February 28, 2026Neurology Open Access0 citationsOpen Access

Adherence to Antiseizure Medications Around Pregnancy

ACAmanda V. Gusovsky ChevalierColumbus State University CLChun Chieh LinThe Ohio State University Wexner Medical Center KKKevin A. KerberThe Ohio State University Wexner Medical Center

Key Points

To investigate the patterns of ASM adherence and discontinuation around pregnancy among individuals with epilepsy.
Examined adherence and discontinuation of ASM around pregnancy in individuals with epilepsy.
Focused on teratogenic exposures while prescribing ASMs like valproate and topiramate.
Compared patient outcomes based on whether they received care from high-volume epilepsy providers.
Identified patterns of ASM adherence and discontinuation during the peripartum period.
Found differences in teratogenic exposure based on provider volume, suggesting better outcomes with experienced providers.

Abstract

Evidence-based care for people with epilepsy of childbearing potential (PWECP) who become pregnant includes prescribing antiseizure medications (ASMs) to minimize seizure frequency while limiting teratogenic exposures (i.e., valproate, topiramate). We aimed to examine peripartum ASM discontinuation and adherence among PWECP; and whether patients seen by high-volume epilepsy providers have different teratogenic ASM exposure.

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