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February 28, 2026Cell Reports0 citationsOpen Access

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

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SXShaozhen XieDana-Farber Cancer InstituteJNJing NiJMJ. Ricardo McFaline-Figueroa

Key Points

  • The study aims to explore how different PI3K isoforms affect glioblastoma when PTEN is absent.
  • Comparison of PI3K isoform activity
  • Assessment of tumor growth and progression
  • Analysis of molecular pathways involved
  • Specific PI3K isoforms significantly influenced tumor behavior
  • Altered signaling pathways were identified
  • Potential therapeutic targets for treatment were suggested

Abstract

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

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Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69a286950a974eb0d3c01ae2https://doi.org/10.1016/j.celrep.2026.117127
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