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This research addresses the occurrence of asymptomatic insulinoma with lymph node metastases and its long-term stability.

February 28, 2026Open Access

A Rare Case of Asymptomatic Insulinoma with Mesocolonic Lymph Node Metastases and Long-Term Stability

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This research addresses the occurrence of asymptomatic insulinoma with lymph node metastases and its long-term stability.
Case report on an asymptomatic insulinoma located in the pancreatic body.
Imaging studies to assess lymph node status in the transverse mesocolon.
Follow-up over a period of at least 3 years to evaluate stability.
The insulinoma was found to have multiple lymph node metastases confined to the mesocolon.
The metastases remained radiologically stable for at least 3 years before diagnosis.
This case underscores the possible malignant behavior of insulinomas, even in low-grade forms.

Resumen

INTRODUCTION: Malignant insulinomas are rare, and lymph node metastases are particularly uncommon in small, low-grade tumors. We report an asymptomatic insulinoma of the pancreatic body with multiple lymph node metastases confined to the transverse mesocolon, which remained radiologically stable for at least 3 years prior to the diagnosis. This case highlights the potential for metastatic disease, even in indolent insulinomas.

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