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February 28, 2026Clinical and Experimental Dermatology

The effect of different therapies and complete blood cell count-derived inflammatory biomarkers on the prognosis of Stevens-Johnson syndrome and toxic epidermal necrolysis

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Authors

PWPei-Yu WangTYTian-Hang YuGYGuangwen Yin

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Overview

Observational study compares treatment outcomes in SJS/TEN patients, suggesting improved prognostic assessment.

Key Points

  • This research aims to compare the efficacy of different therapies for SJS/TEN and identify inflammatory biomarkers related to prognosis.
  • Analyzed SJS/TEN inpatients treated with corticosteroid combinations or monotherapy from 2015 to 2024.
  • Calculated inflammatory biomarkers including NLR, dNLR, MLR, PLR, and NLPR.
  • Examined correlations between these biomarkers and disease severity and prognosis.
  • Mortality rates were lower than expected across treatment groups.
  • Patients receiving corticosteroid with adalimumab or IVIG showed faster improvement than those on corticosteroid monotherapy.
  • Biomarkers NLR, dNLR, PLR, and NLPR were linked to worsening SCORTEN scores, while MLR indicated slower healing.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a286b80a974eb0d3c01d9bhttps://doi.org/10.1093/ced/llag088
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