Synthesis of a hydrophilic covalent-organic framework@silica composites via oxidation reaction for mixed-mode liquid chromatographic separation

Key Points

• The aim is to synthesize a hydrophilic covalent-organic framework-silica composite for enhanced chromatographic separation.
• Utilized oxidation reaction for synthesis
• Employed 2,4,6-tris(4-aminophenyl-1,3,5-thiazine) and 1,4-benzenedicarboxaldehyde as monomers
• Conducted a one-pot cascade polymerization reaction on silica spheres
• Successfully synthesized a hydrophilic covalent-organic framework@silica composite
• Demonstrated effective separation in mixed-mode liquid chromatography
• Indicated improved performance for complex sample analysis